The spike receptor-binding motif G496S substitution determines the replication fitness of SARS-CoV-2 Omicron sublineageArticle Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] approach Cell culture circulating comparable contribute COVID-19 determine experimental animal models fitness. G496S genetics monoclonal antibodies omicron Omicron BA.1 Omicron BA.2 pathogenicity phenotype predominant receptor-binding motif Replication SARS-CoV-2 SARS-CoV-2 variant sensitivity spike mutation therapeutic trajectory [DOI] 10.1080/22221751.2022.2111977 PMC 바로가기
SARS-CoV-2 infects human brain organoids causing cell death and loss of synapses that can be rescued by treatment with SofosbuvirArticle Published on 2022-11-032022-11-15 Journal: PLoS Biology [Category] SARS, 치료제, [키워드] accompanied Affect alleviate alteration Antiviral antivirals Brain brain organoid brain organoids cell death cells cellular coronavirus 2 coronavirus disease cortical COVID-19 death determine drug excitatory food infect inhibit SARS-CoV-2 neurological manifestation Neurological symptoms neuronal neurons Newborn pandemic phenotype promote replicate Replication rescued respiratory respiratory illnesses SARS-CoV-2 sofosbuvir Treatment underlie variety WHO World Health Organization [DOI] 10.1371/journal.pbio.3001845 PMC 바로가기
Single-cell transcriptomic atlas reveals distinct immunological responses between COVID-19 vaccine and natural SARS-CoV-2 infectionArticle Published on 2022-11-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] Activation acute respiratory syndrome alteration analysis antibody production Apoptosis B cell caused collected CoronaVac coronavirus COVID-19 COVID-19 infected patient COVID-19 patients COVID-19 vaccine cytotoxicity downregulation Emergency use authorization expression expression of gene feature greater HLA class II IL21R immune Immune cell immune cell types immune response immunization immunized immunological Immunological response immunological responses inactivated Inactivated vaccine individual individuals Infection Inflammatory cytokine innate immune cell interferon response magnitude mechanism Migration mononuclear cells naïve B cell naïve B cells pandemic PBMC Peripheral blood phenotype plasma profile Proinflammatory cytokine proportion provide reveal SARS-CoV-2 SARS-COV-2 infection scRNA-seq Sequencing severe disease single-cell Single-cell RNA sequencing single-cell sequencing. Sinovac systemic immune response T cell thrombosis transcriptomic upregulation vaccine-induced immune response [DOI] 10.1002/jmv.28012 PMC 바로가기
Type D lymphomatoid papulosis with pityriasis lichenoides et varioliformis acuta-like features in a child with parvovirus infection: a controversial diagnosis in the spectrum of lymphoid proliferations: case report and literature reviewArticle Published on 2022-10-282022-11-16 Journal: Italian Journal of Pediatrics [Category] COVID19(2023년), SARS, 치료기술, [키워드] Administered Alanine antigenic Aspartate aminotransferase Bilirubin C-reactive protein Case report CD8+/CD30+ cells children clinical response clinical suspicion Critical cytokine profile Cytokines Department Diagnosis differential diagnosis discharged disease disorder Emergency erythematous feature Fever histological history Hospitalized IFN-γ IL-10 IL-6 immunoglobulin M infectious agent infiltration introduced Laboratory test lesion lesions limits literature review lymphoid lymphomatoid Lymphomatoid papulosis lymphoproliferative Lymphoproliferative cutaneous disorders marker mechanism monoclonal morphologically necrotic Parvovirus parvovirus B19 pathogenic Perspective phenotype pityriasis lichenoides et varioliformis acuta. polymerase chain reaction positive response proliferation Rash recorded regions reported representing returned SARS-CoV-2 antigen separated skin lesions steroid Support Symptom systemic corticosteroid T-cell receptor Therapies Treatment Type Type D [DOI] 10.1186/s13052-022-01371-x PMC 바로가기
Immunological and Pathological Peculiarity of Severe Acute Respiratory Syndrome Coronavirus 2 Beta VariantArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, [키워드] Activation acute respiratory syndrome analysis Beta Beta variant blockade cascade cause CCL2 Characteristics Comparative analysis coronavirus coronavirus 2 COVID-19 COVID-19 pandemic CXCR2 cytokine cytokine release death Disease progression early stage evidenced IL-1β immunological induce Infection Inflammatory cytokine investigated K18-hACE2 late stage Lung pathology mice molecular mechanism Mortality neutrophil recruitment outbreak pathological pathological condition pathology phenotype presymptomatic provide reduced respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis SARS-CoV-2 variant secreted cytokine Strains the SARS-CoV-2 Transcriptome transcriptomes Transmissibility Treatment variant Variant. viral infection weight loss [DOI] 10.1128/spectrum.02371-22 PMC 바로가기
A comprehensive update on CIDO: the community-based coronavirus infectious disease ontologyArticle Published on 2022-10-212022-11-16 Journal: Journal of Biomedical Semantics [Category] COVID19(2023년), SARS, 변종, 신약개발, [키워드] aligned Amino acid amino acid substitution Analysis applied basic Clinical data clinical trial coronavirus coronavirus coronavirus disease COVID-19 COVID-19 pandemic Delta Diagnosis diagnostic disease domain drug Drug repurposing drug-target effective Epidemiology evaluated example Formal global public health heterogeneous Human Infectious disease initiated knowledge Metadata omicron ontologies Ontology outbreak phenotype PPI protein-protein interaction Safe SARS-CoV-2 SARS-CoV-2 protein Standardization Support supported target protein Treatment Vaccine vaccine. variant variants variants of SARS-CoV-2 virus [DOI] 10.1186/s13326-022-00279-z PMC 바로가기
Prevention of ribosome collision-induced neuromuscular degeneration by SARS CoV-2-encoded Nsp1Article Published on 2022-10-182022-11-16 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ABCE1 abort acute respiratory syndrome affecting AKT Alzheimer’s disease autophagy biochemical analysis combating condition coronavirus COVID-19 pandemic Critical disease Diseases Drosophila effective exhibited Factors Genetic Host hosts mechanism modify neurodegenerative nonstructural protein 1 nsp1 overexpression pathogenic mechanism phenotype prevention Protein Quality control quality-control rescued Research ribosome collision ribosome-associated quality control. ribosomes SARS-CoV-2 Signaling specificity therapeutic strategy translation Treatment virus [DOI] 10.1073/pnas.2202322119 PMC 바로가기
Longitudinal characterization of circulating neutrophils uncovers phenotypes associated with severity in hospitalized COVID-19 patientsArticle Published on 2022-10-182022-11-15 Journal: Cell Reports Medicine [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome antibody profiling blood sample cell death circulating neutrophil contributing to Control coronavirus COVID-19 degranulation disease disease severity driver dysregulated elevated experiment functions G-MDSC gene expression signature Granulocytic healthy donor hospitalized COVID-19 hospitalized COVID-19 patient Humoral response identify IgA IgA antibody IgG antibody Immunoglobulin induce longitudinal Mortality NETosis neutrophil Neutrophils Patient phagocytosis phenotype plasma plasma proteomics response RNA sequencing SARS-CoV-2 severe coronavirus disease severe COVID-19 severe disease Severe patient severity Subtypes survived transcriptomics transcriptomics. [DOI] 10.1016/j.xcrm.2022.100779 PMC 바로가기
Genetic variants determine intrafamilial variability of SARS-CoV-2 clinical outcomes in 19 Italian familiesArticle Published on 2022-10-132022-11-15 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] acute respiratory syndrome addition Analysis association carried characterized clinical expression Clinical outcome clinical variability coronavirus COVID-19 determine disease genetic background genetic profile heterogeneity Host host response Immunity Infection Interaction involved Italian multifactorial occurred outcome performed Perspective phenotype positive protective effect rare variant risk SARS-CoV-2 shown SNPs statistical analysis statistically significant subject susceptibility the disease Transmission Transmission dynamics Vaccine Variability variant viral infection virus virus entry [DOI] 10.1371/journal.pone.0275988 PMC 바로가기
Booster dose of mRNA vaccine augments waning T cell and antibody responses against SARS-CoV-2Article Published on 2022-10-122022-11-16 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] activated T cell antibodies antibody Antibody Response booster booster dose booster vaccination CD137 CD69 CD8 T cell Cellular immune response ChAdOx1-S conducted decrease dose expressing expression Frequency humoral IFN-γ immune response immunosuppressive increase in indicated Infection Injections lack longitudinal analysis memory monocyte mRNA mRNA vaccine myeloid cell omicron participant PD-L1 peptides phenotype producing protective immunity reactive reduced SARS-CoV-2 SARS-CoV-2-specific T cell T cell T cell response T cells the spike protein TNF-α upregulation vaccination Vaccinations Vaccine variant vector vaccine. virus-specific T cell [DOI] 10.3389/fimmu.2022.1012526 PMC 바로가기